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BBC Health --
The active ingredient in marijuana may stall decline from Alzheimer's
disease, research suggests. Scientists showed a synthetic version of
the compound may reduce inflammation associated with Alzheimer's and
thus help to prevent mental decline. They hope the cannabinoid may be
used to developed new drug therapies. The research, by Madrid's
Complutense University and the Cajal Institute, is published in the
Journal of Neuroscience. The scientists first compared the brain
tissue of patients who died from Alzheimer's disease with that of
healthy people who had died at a similar age. They looked closely at
brain cell receptors to which cannabinoids bind, allowing their effects
to be felt. They also studied structures called microglia, which
activate the brain's immune response. Microglia collect near the plaque
deposits associated with Alzheimer's disease and, when active, cause
inflammation. The researchers found a dramatically reduced functioning
of cannabinoid receptors in diseased brain tissue. This was an
indication that patients had lost the capacity to experience
cannabinoids' protective effects. The next step was to test the effect
of cannabinoids on rats injected with the amyloid protein that forms
Alzheimer's plaques. Those animals who were also given a dose of a
cannabinoid performed much better in tests of their mental functioning.
The researchers found that the presence of amyloid protein in the rats'
brains activated immune cells. However, rats that also received the
cannabinoid showed no sign of microglia activation. Using cell
cultures, the researchers confirmed that cannabinoids counteracted the
activation of microglia and thus reduced inflammation. Researcher Dr
Maria de Ceballos said: "These findings that cannabinoids work both to
prevent inflammation and to protect the brain may set the stage for
their use as a therapeutic approach for Alzheimer's disease." (02/23/05) |
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BBC Science --
A huge, frozen sea lies just below the surface of Mars, a team of
European scientists has announced. Their assessment is based on
pictures of the planet's near-equatorial Elysium region that show
plated and rutted features across an area 800 by 900km. The team think
a catastrophic event flooded the landscape five million years ago and
then froze out. They tell a forthcoming edition of Nature magazine that
sediments covered the ice, locking it in place. Large reserves of
water-ice are known to be held at the poles on Mars but if this
discovery is confirmed by follow-up observations, it would be a first
for a region at such a low latitude. "It's been predicted for a long
time that you should find water close to the surface of Mars near the
equator," Jan-Peter Muller, from University College London, UK,
said. "This is an area where there are a lot of river
features but no-one has ever seen a sea before, and certainly no-one
has ever seen pack ice before," he told the BBC News website. The
interpretation is based on images taken by the High Resolution Stereo
Camera on Europe's Mars Express spacecraft. These show extensive fields
of large, platy features - reminiscent of the fractured ice floes found
in polar regions on Earth. Finding exposed ice at the equator would be
unlikely. Very low pressures on the planet would lead to sublimation -
the ice would erode over time straight to water vapour. But the
research group, led by John Murray, from the Open University, UK, tells
Nature that a crust of dust and volcanic ash, perhaps just a few
centimetres thick, has prevented this happening. "The story runs that
water flowed in some kind of massive catastrophic event; pack ice
formed on top of that water and broke up, and then the whole thing
froze rigid," explains Professor Muller. (02/23/05) |
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BBC Science -- Astronomers
say they have discovered an object that appears to be an invisible
galaxy made almost entirely of dark matter. The team, led by Cardiff
University, claimed it is the first to be detected. A dark galaxy is an
area in the Universe containing a large amount of mass that rotates
like a galaxy, but contains no stars. It was found 50 million light
years away using radio telescopes in Cheshire and Puerto Rico. The
unknown material that is thought to hold these dark galaxies together
is known as 'dark matter', but scientists still know very little about
what that is. The five-year research has involved studying the
distribution of hydrogen atoms throughout the Universe, estimated by
looking at the rotation of galaxies and the speed at which their
components moved. Hydrogen gas releases radiation that can be detected
at radio wavelengths. In the Virgo cluster of galaxies, they found a
mass of hydrogen atoms a hundred million times the mass of the Sun. The
mysterious galaxy has been called VIRGOHI21. Similar objects that have
previously been discovered have since turned out to contain stars or be
remnants of two galaxies colliding. However, the scientists from the
UK, France, Italy and Australia found no visible trace of any stars,
and no galaxies nearby that would suggest a collision. Dr Robert
Minchin, of Cardiff University, said: "From its speed, we realised that
VIRGOHI21 was a thousand times more massive than could be accounted for
by the observed hydrogen atoms alone. If it were an ordinary galaxy,
then it should be quite bright and would be visible with a good amateur
telescope." (02/23/05) |
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This page was last updated: Wednesday, February 23, 2005 at 4:18:24 PM TrustMark 2005 by the SynEARTH.network.

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